REMARKABLE PROTECTIVE EFFECTS OF NRF2-MEDIATED ANTIOXIDANT ENZYMES AND TISSUE SPECIFICITY IN DIFFERENT SKELETAL MUSCLES OF DAURIAN GROUND SQUIRRELS OVER THE TORPOR-AROUSAL CYCLE

Remarkable Protective Effects of Nrf2-Mediated Antioxidant Enzymes and Tissue Specificity in Different Skeletal Muscles of Daurian Ground Squirrels Over the Torpor-Arousal Cycle

Hibernating mammals experience conditions of extreme oxidative stress, such as fasting, muscle disuse, and repeated hypoxic ischemia-reperfusion, during the torpor-arousal cycle.Despite this, they experience little oxidative injury and are thus an interesting model of anti-oxidative damage.Thus, in the current study, we explored the levels and unde

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CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy

Tumor microenvironments are rich in extracellular nucleotides that can be metabolized by ectoenzymes to produce adenosine, a nucleoside involved in controlling immune responses.Multiple myeloma, a plasma cell malignancy developed within a bone marrow niche, exploits adenosinergic pathways to customize the immune homeostasis of the tumor.CD38, a mul

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